期刊
GENOME BIOLOGY
卷 18, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s13059-017-1311-2
关键词
Tumor evolution; Intra-tumor heterogeneity; Single-cell sequencing; Finite-sites model; Phylogenetic tree
资金
- National Cancer Institute [R01 CA172652]
- NCI-Designated cancer center [P30 CA016672]
- Andrew Sabin Family Foundation
Single-cell sequencing enables the inference of tumor phylogenies that provide insights on intra-tumor heterogeneity and evolutionary trajectories. Recently introduced methods perform this task under the infinite-sites assumption, violations of which, due to chromosomal deletions and loss of heterozygosity, necessitate the development of inference methods that utilize finite-sites models. We propose a statistical inference method for tumor phylogenies from noisy single-cell sequencing data under a finite-sites model. The performance of our method on synthetic and experimental data sets from two colorectal cancer patients to trace evolutionary lineages in primary and metastatic tumors suggests that employing a finite-sites model leads to improved inference of tumor phylogenies.
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