期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 74, 期 19, 页码 3553-3575出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2586-x
关键词
Adult cells; Chemical compound; Direct conversion; Tissue repair; Regeneration
资金
- National Nature Science Foundation of China [81121004, 81230041]
- National Basic Science and Development Program (973 Program) [2012CB518105]
Pluripotency reprogramming and transdifferentiation induced by transcription factors can generate induced pluripotent stem cells, adult stem cells or specialized cells. However, the induction efficiency and the reintroduction of exogenous genes limit their translation into clinical applications. Small molecules that target signaling pathways, epigenetic modifications, or metabolic processes can regulate cell development, cell fate, and function. In the recent decade, small molecules have been widely used in reprogramming and transdifferentiation fields, which can promote the induction efficiency, replace exogenous genes, or even induce cell fate conversion alone. Small molecules are expected as novel approaches to generate new cells from somatic cells in vitro and in vivo. Here, we will discuss the recent progress, new insights, and future challenges about the use of small molecules in cell fate conversion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据