期刊
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
卷 529, 期 -, 页码 475-486出版社
ELSEVIER
DOI: 10.1016/j.colsurfa.2017.06.036
关键词
Green synthesis; Silver nanoparticles; Chitosan hydrogels; Burn-wound infections; Radical scavenging assay
Methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (PA) infections in thermally injured patients have led to intrusive disease causing mortality. Silver nanoparticles (AgNPs) employed in treatment have limitations owing to their oxidative damage and toxicity in tissues. Present study focuses on the synthesis of biocompatible AgNPs from antioxidant-rich aqueous extract of Aerva javanica. Capping of phenols on AgNPs surface was confirmed through FTIR analysis and hence spherically assembled particles of low polydispersity index exhibited Surface Plasmon Resonance at 430 nm. These assembled antibacterial AgNPs were assessed for their radical scavenging properties and cytotoxic potential on both primary (HCEC) and cancerous cell lines (Huh-7, HeLa). Potential agglomeration of intraperitoneally administered AgNPs (3-24 mg kg-1) in liver, spleen and kidney of balb/c mice was assessed through histological analysis and corresponding mortality and weight loss studies were evaluated. These AgNPs after incorporation in chitosan hydrogels were topically applied on partial thickness burn wound infections (2x10(8) CFUs of MRSA and PA) created in Balb/c mice. A significant reduction in the infection was observed with application of AgNPs incorporated hydrogels that improved the healing time.
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