期刊
CHILDS NERVOUS SYSTEM
卷 33, 期 10, 页码 1663-1667出版社
SPRINGER
DOI: 10.1007/s00381-017-3530-y
关键词
Children; Pediatric neurotrauma; Severe traumatic brain injury; Pediatric neurocritical care; Comparative effectiveness research; Evidenced-based guidelines
资金
- National Institute of Neurological Disorders and Stroke of the National Institutes of Health [U01 NS081041]
Traumatic brain injury (TBI) is a leading killer of children in the developed and developing world. Despite evidence-based guidelines and several recent clinical trials, the progress in developing best practices for children with severe TBI has been slow. This article describes (i) the burden of the disease, (ii) the inadequacies of the evidence-based guidelines, (iii) the failure of the largest clinical trials to prove their primary hypotheses, and (iv) possible advances from an observational cohort study called the Approaches and Decisions for Acute Pediatric TBI (ADAPT) Trial that has recently completed enrollment.
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