期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 38, 页码 11515-11519出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201706374
关键词
allylation; catalysis; iridium; piperidines; stereoselective synthesis
资金
- ETH Zurich
- Swiss National Science Foundation [200020_152898]
- Swiss National Science Foundation (SNF) [200020_152898] Funding Source: Swiss National Science Foundation (SNF)
An iridium-catalyzed cyclocondensation of amino alcohols and aldehydes is reported. Intramolecular allylic substitution by an enamine intermediate and subsequent in situ reduction furnishes 3,4-disubstituted piperidines with high enantiospecificity and good diastereoselectivity. The modular approach and the broad functional group tolerance provide access to diverse piperidine derivatives, which were further functionalized to give a versatile set of products.
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