期刊
CURRENT PHARMACEUTICAL DESIGN
卷 23, 期 21, 页码 3134-3141出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612823666170309151958
关键词
Dendrimers; nanoparticles; vaccines; adjuvant; antigen; antibody
资金
- federal funds from the National Cancer Institute
- National Institutes of Health [HHSN261200800001E]
Background: Dendrimers are hyperbranched polymeric nanomaterials increasingly used in research, industrial and biomedical applications. Establishing safety profile of these particles includes an understanding of their interactions with blood components and the immune system. Method: Herein I review the literature demonstrating how tuning dendrimer physicochemical properties influences their interaction with erythrocytes, platelets, plasma proteins, complement and coagulation systems. Dendrimer immunogenicity, adjuvanticity, allergenicity, anti-inflammatory, immunosuppressive and antibacterial properties are also discussed. Conclusion: Dendrimers hemato- and immune-compatibility are determined by particle size, architecture, type and density of surface functional groups. Case studies from the literature are discussed to support this conclusion. The review also highlights questions which require more thorough investigation to fill the gaps in our understanding of immunological properties of dendrimers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据