期刊
MATERIALS
卷 10, 期 8, 页码 -出版社
MDPI AG
DOI: 10.3390/ma10080973
关键词
polydimethylsiloxane (PDMS); micro-patterns; RGD-phage; cell-surface interaction; rat H9c2 cardiomyocytes
类别
资金
- Korea Institute of Science and Technology Europe (KIST-Europe) [11705]
A micro-patterned cell adhesive surface was prepared for future design of medical devices. One-dimensional polydimethylsiloxane (PDMS) micro-patterns were prepared by a photolithography process. Afterwards, recombinant filamentous phages that displayed a short binding motif with a cell adhesive peptide (-RGD-) on p8 proteins were immobilized on PDMS microgrooves through simple contact printing to study the cellular response of rat H9c2 cardiomyocyte. While the cell density decreased on PDMS micro-patterns, we observed enhanced cell proliferation and cell to surface interaction on the RGD-phage coated PDMS microgrooves. The RGD-phage coating also supported a better alignment of cell spreading rather than isotropic cell growths as we observed on non-pattered PDMS surface.
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