期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 90, 期 4, 页码 590-595出版社
WILEY
DOI: 10.1111/cbdd.12982
关键词
4-aminoquinoline-ferrocenyl-chalcone; aldol condensation; antiplasmodial activities; structure-activity relationship
资金
- Science and Engineering Research Board [EMR/2015/001687]
- University Grants Commission
- EU-V
A series of piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates were prepared with a view to evaluate their activities against Plasmodium falciparum. The synthesized conjugates had in vitro IC50 values from 0.41 to 2.38m against chloroquine-resistant and mefloquine-sensitive W2 strain of P.falciparum. The submicromolar activities of most of the synthesized conjugates suggest that such molecular frameworks can act as therapeutic templates for the design and synthesis of new antimalarials.
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