期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1865, 期 10, 页码 1255-1266出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2017.07.006
关键词
Type II secretion system; Dynamics; Intrinsic disorder; Type IV pilus; Type III secretion system; Virulence; Secretin; Gram negative bacteria; Pathogen; Secretion
资金
- Medical Research Council [MR/M009920/1]
- CNRS [PICS 161532]
- Biological and Biotechnological Sciences Research Council [BB/M002969/1]
- Higher Education Funding Council for England
- Queen Mary University of London
- Medical Research Council [MR/M009920/1] Funding Source: researchfish
- MRC [MR/M009920/1] Funding Source: UKRI
Many Gram-negative commensal and pathogenic bacteria use a type II secretion system (T2SS) to transport proteins out of the cell. These exported proteins or substrates play a major role in toxin delivery, maintaining biofilms, replication in the host and subversion of host immune responses to infection. We review the current structural and functional work on this system and argue that intrinsically disordered regions and protein dynamics are central for assembly, exo-protein recognition, and secretion competence of the T2SS. The central role of intrinsic disorder-order transitions in these processes may be a particular feature of type secretion.
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