期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 40, 页码 12273-12276出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201706270
关键词
decarboxylation; heterocycles; photochemistry; radicals; synthetic methods
资金
- Alexander von Humboldt Foundation
The visible-light-promoted decarboxylation of -imino-oxy propionic acids for the generation of iminyl radicals has been accomplished through the use of Ir(dFCF(3)ppy)(2)(dtbbpy)PF6 as a photoredox catalyst. Different from visible-light-promoted homolysis and single-electron reduction of oxime derivatives, this strategy provides a novel catalytic cycle for alkene carboimination through a sequence comprising N-radical generation, iminyl radical cyclization, intermolecular conjugate addition to a Michael acceptor, and single-electron reduction to afford various pyrroline derivatives in an overall redox-neutral process. The indolizidine alkaloid skeleton could be easily constructed from a pyrroline derivative prepared by this synthetic method.
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