期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 38, 页码 32475-32481出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b07569
关键词
BODIPY; heavy atom effect; configuration; Hela; photodynamic therapy
资金
- NNSF of China [61525402, 61775095, 61604071]
- Key University Science Research Project of Jiangsu Province [15KJA430006]
- Natural Science Foundation of Jiangsu Province [BK20161012]
Heavy atom effect and configuration are important for BODIPY derivatives to generate singlet oxygen (O-1(2)) for photodynamic therapy. Herein, a series of BODIPY derivatives with different halogens were synthesized. O-1(2) quantum yields (QYs) and MTT assay confirm that incorporation of more heavy atoms onto dimeric BODIPY cannot effectively enhance the O-1(2) QYs. Rather, the dark toxicity increases. This phenomenon can be attributed to the competition of heavy atom effect and configuration of dimeric BODIPY. In addition the BODIPY derivative with two iodine atoms (BDPI) owns the highest O-1(2) QYs (73%) and the lowest phototoxicity ICso (1 yM)..Furthermote, an in vivo study demonstrates that BDPI NPs can effectively inhibit tumor growth and can be used as a promising threanostic agent for photodynamic therapy in clinic.
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