期刊
DOMESTIC ANIMAL ENDOCRINOLOGY
卷 61, 期 -, 页码 48-53出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.domaniend.2017.06.003
关键词
Dairy cow; Insulin resistance; Insulin sensitivity; Intravenous glucose tolerance test; Transition period
资金
- Sir Kenneth Blaxter Award of the British Society for Animal Science
The aim of this study was to investigate the correlation between different surrogate indices and parameters of the intravenous glucose tolerance test (IVGTT) in dairy cows at the start of their lactation. Ten dairy cows underwent IVGTT on Days 3 to 7 after calving. Areas under the curve during the 90 min after infusion, peak and nadir concentrations, elimination rates, and times to reach half-maximal and basal concentrations for glucose, insulin, nonesterified fatty acids, and beta-hydroxybutyrate were calculated. Surrogate indices were computed using the average of the IVGTT basal samples, and their correlation with the IVGTT parameters studied through the Spearman's rank test. No statistically significant or strong correlation coefficients (P > 0.05; |p| < 0.50) were observed between the insulin sensitivity measures derived from the IVGTT and any of the surrogate indices. Therefore, these results support that the assessment of insulin sensitivity in early lactation cattle cannot rely on the calculation of surrogate indices in just a blood sample, and the more laborious tests (ie, hyperinsulinemic euglycemic clamp test or IVGTT) should be employed to predict the sensitivity of the peripheral tissues to insulin accurately. (C) 2017 Elsevier Inc. All rights reserved.
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