期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 39, 页码 11875-11879出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201706763
关键词
desymmetrization; fluorine; organocatalysis; photochemistry; synthetic methods
资金
- Generalitat de Catalunya (CERCA Program)
- MINECO [CTQ2016-75520-P, SEV-2013-0319]
- European Research Council [ERC 681840-CATA-LUX]
- MECD [FPU14/06541]
- Marie Curie COFUND action [2014-1-ICIQ-IPMP]
Reported herein is a light-triggered organocatalytic strategy for the desymmetrization of achiral 2-fluoro-substituted cyclopentane-1,3-diketones. The chemistry is based on an intermolecular aldol reaction of photochemically generated hydroxy-o-quinodimethanes and simultaneously forges two adjacent fully substituted carbon stereocenters, with one bearing a stereogenic carbon-fluorine unit. The method uses readily available substrates, a simple chiral organocatalyst, and mild reaction conditions to afford an array of highly functionalized chiral 2-fluoro-3-hydroxycyclopentanones.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据