期刊
AUTOIMMUNITY REVIEWS
卷 16, 期 9, 页码 951-962出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2017.07.008
关键词
Inflammation; Endothelial cells; Angiogenesis; Immune regulation; Endothelial-to-mesenchymal transition (EndMT); Targeted therapies
类别
资金
- ZonMw [90700359]
- Dutch Arthritis Foundation [2015-2-015, 2016-1-032]
- ReumaFonds [16-1-302, 15-2-401] Funding Source: researchfish
The endothelium is crucially important for the delivery of oxygen and nutrients throughout the body under homeostatic conditions. However, it also contributes to pathology, including the initiation and perpetuation of inflammation. Understanding the function of endothelial cells (ECs) in inflammatory diseases and molecular mechanisms involved may lead to novel approaches to dampen inflammation and restore homeostasis. In this article, we discuss the various functions of ECs in inflammation with a focus on pathological angiogenesis, attraction of immune cells, antigen presentation, immunoregulatory properties and endothelial-to-mesenchymal transition (EndMT). We also review the current literature on approaches to target these processes in ECs to modulate immune responses and advance anti-inflammatory therapies. (C) 2017 The Author(s). Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据