期刊
YONSEI MEDICAL JOURNAL
卷 58, 期 6, 页码 1083-1091出版社
YONSEI UNIV COLL MEDICINE
DOI: 10.3349/ymj.2017.58.6.1083
关键词
Gut microbiota; gut immunity; obesity; diabetes
资金
- Global Research Laboratory [K21004000003-12A0500-00310]
- Bio & Medical Technology Development Program [NRF-2015M3A9B6073846]
- UNIST Fund [2014 M3A9D8034459]
- Samsung Medical Center grant [CRP 1500058]
Gut microbiota play critical physiological roles in energy extraction from the intestine and in the control of systemic immunity, as well as local intestinal immunity. Disturbance of gut microbiota leads to the development of several diseases, such as colitis, inflammatory bowel diseases, metabolic disorders, cancer, etc. From a metabolic point of view, the gut is a large metabolic organ and one of the first to come into contact with dietary fats. Interestingly, excessive dietary fat has been incriminated as a primary culprit of metabolic syndrome and obesity. After intake of high-fat diet or Western diet, extensive changes in gut microbiota have been observed, which may be an underlying cause of alterations in whole body metabolism and nutrient homeostasis. Here, we summarize recent data on changes in the gut microbiota and immunity associated with dietary fat, as well as their relationships with the pathogenesis of metabolic syndrome. These findings may provide insight into the understanding of the complex pathophysiology related to the development of metabolic diseases and offer an opportunity to develop novel candidates for therapeutic agents.
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