期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 74, 期 19, 页码 3533-3552出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2539-4
关键词
Psychiatric behavior; Radial neuronal migration; Cytoskeleton; Treatment strategy; CAMDI
资金
- Grants-in-Aid for Scientific Research [17K08793, 26293072] Funding Source: KAKEN
Normal development of the cerebral cortex is an important process for higher brain functions, such as language, and cognitive and social functions. Psychiatric disorders, such as schizophrenia and autism, are thought to develop owing to various dysfunctions occurring during the development of the cerebral cortex. Radial neuronal migration in the embryonic cerebral cortex is a complex process, which is achieved by strict control of cytoskeletal dynamics, and impairments in this process are suggested to cause various psychiatric disorders. Our recent findings indicate that radial neuronal migration as well as psychiatric behaviors is rescued by controlling microtubule stability during the embryonic stage. In this review, we outline the relationship between psychiatric disorders, such as schizophrenia and autism, and radial neuronal migration in the cerebral cortex by focusing on the cytoskeleton and centrosomes. New treatment strategies for psychiatric disorders will be discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据