期刊
JOURNAL OF GASTROINTESTINAL ONCOLOGY
卷 8, 期 5, 页码 758-765出版社
AME PUBL CO
DOI: 10.21037/jgo.2017.08.05
关键词
Adjuvant radiation; pancreatic cancer; lymph node harvest; outcomes in the elderly population
资金
- NCI NIH HHS [P30 CA076292] Funding Source: Medline
Background: We sought to determine the effects of post- operative radiation therapy (PORT) and lymph node resection (LNR) on survival in patients >= 70 years with pancreatic cancer treated with surgery and chemotherapy. Methods: An analysis of patients >= 70 years with surgically resected pancreatic cancer who received chemotherapy from the SEER database between 2004- 2008 was performed to determine association of PORT and LNR on survival. Results: We identified 961 patients who met inclusion criteria. There was a trend towards increased survival associated with PORT in all patients (P=0.052) and N1 patients (P=0.060) but no benefit in N0 patients (P=0.161). There was no difference in OS based on number of lymph nodes removed in all (P=0.741), N0 (P=0.588), and N1 (P=0.070) patients. MVA for all patients revealed that higher T stage, N1, and high grade tumors were prognostic for increased mortality, while there was decreased mortality with PORT and mild benefit with increased lymph nodes resected (P=0.084). Conclusions: PORT demonstrated no benefit in survival of pancreatic cancer patients >= 70 who are resected and treated with adjuvant chemotherapy. Future investigation will need to address age as a stratification factor for pancreatic cancer in the adjuvant setting.
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