期刊
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
卷 7, 期 -, 页码 23-30出版社
ELSEVIER
DOI: 10.1016/j.cogsc.2017.06.002
关键词
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资金
- Deutsche Forschungsgemeinschaft [HA 7668/1-1]
- National Science Foundation Graduate Research Fellowship [1144469]
- National Science Foundation
- Office of Chemical, Bioengineering, Environmental and Transport Systems SusChEM Initiative [CBET-1403077]
- Division of Molecular and Cellular Biosciences [MCB-1513007]
- Defense Advanced Research Projects Agency Biological Robustness in Complex Settings Contract [HR0011-15-C-0093]
- Caltech Innovation Initiative (CI2) Program
- Jacobs Institute for Molecular Engineering for Medicine at Caltech
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1403077] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1513007] Funding Source: National Science Foundation
Enzymes are used in biocatalytic processes for the efficient and sustainable production of pharmaceuticals, fragrances, fine chemicals, and other products. Most bioprocesses exploit chemistry found in nature, but we are now entering a realm of biocatalysis that goes well beyond. Enzymes have been engineered to catalyze reactions previously only accessible with synthetic catalysts. Because they can be tuned by directed evolution, many of these new biocatalysts have been shown to perform abiological reactions with high activity and selectivity. We discuss recent examples, showcase catalyst improvements achieved using directed evolution, and comment on some current and future implications of nonnatural enzyme evolution for sustainable chemical synthesis.
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