期刊
CLINICAL NEUROPHYSIOLOGY
卷 128, 期 10, 页码 2029-2036出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2017.07.419
关键词
Tremor detection; Parkinson's disease; Neuronal oscillations; Deep brain stimulation; Subthalamic nucleus; Hidden Markov Model
资金
- German Federal Ministry of Education and Research (BMBF)
- German Academic Exchange Service (DAAD)
- The Netherlands Organisation for Scientific Research [639.072.513, 864.14.011]
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7) under REA grant [605728]
Objective To investigate the possibility of tremor detection based on deep brain activity.& para;& para;Methods We re-analyzed recordings of local field potentials (LFPs) from the subthalamic nucleus in 10 PD patients (12 body sides) with spontaneously fluctuating rest tremor. Power in several frequency bands was estimated and used as input to Hidden Markov Models (HMMs) which classified short data segments as either tremor-free rest or rest tremor. HMMs were compared to direct threshold application to individual power features.& para;& para;Results Applying a threshold directly to band-limited power was insufficient for tremor detection (mean area under the curve [AUC] of receiver operating characteristic: 0.64, STD: 0.19). Multi-feature HMMs, in contrast, allowed for accurate detection (mean AUC: 0.82, STD: 0.15), using four power features obtained from a single contact pair. Within-patient training yielded better accuracy than across-patient training (0.84 vs. 0.78, p = 0.03), yet tremor could often be detected accurately with either approach. High frequency oscillations (>200 Hz) were the best performing individual feature.& para;& para;Conclusions LFP-based markers of tremor are robust enough to allow for accurate tremor detection in short data segments, provided that appropriate statistical models are used. Significance LFP-based markers of tremor could be useful control signals for closed-loop deep brain stimulation. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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