期刊
AUTISM RESEARCH
卷 10, 期 10, 页码 1672-1686出版社
WILEY
DOI: 10.1002/aur.1817
关键词
Autism Diagnostic Interview-Revised; Autism Diagnostic Observation Schedule; early diagnosis; screening
资金
- South-Eastern Norway Regional Health Authority [2012101]
- National Institutes of Health/National Institute of Neurological Disorders and Stroke [U01 NS047537]
- MRC [MC_UU_12013/1] Funding Source: UKRI
- Medical Research Council [MC_UU_12013/1] Funding Source: researchfish
The parental report-based Autism Diagnostic Interview-Revised (ADI-R) and the clinician observation-based Autism Diagnostic Observation Schedule (ADOS) have been validated primarily in U.S. clinics specialized in autism spectrum disorder (ASD), in which most children are referred by their parents because of ASD concern. This study assessed diagnostic agreement of the ADOS-2 and ADI-R toddler algorithms in a more broadly based sample of 679 toddlers (age 35-47 months) from the Norwegian Mother and Child Cohort. We also examined whether parental concern about ASD influenced instrument performance, comparing toddlers identified based on parental ASD concern (n=48) and parent-reported signs of developmental problems (screening) without a specific concern about ASD (n=400). The ADOS cutoffs showed consistently well-balanced sensitivity and specificity. The ADI-R cutoffs demonstrated good specificity, but reduced sensitivity, missing 43% of toddlers whose parents were not specifically concerned about ASD. The ADI-R and ADOS dimensional scores agreed well with clinical diagnoses (area under the curve0.85), contributing additively to their prediction. On the ADI-R, different cutoffs were needed according to presence or absence of parental ASD concern, in order to achieve comparable balance of sensitivity and specificity. These results highlight the importance of taking parental concern about ASD into account when interpreting scores from parental report-based instruments such as the ADI-R. While the ADOS cutoffs performed consistently well, the additive contributions of ADI-R and ADOS scores to the prediction of ASD diagnosis underscore the value of combining instruments based on parent accounts and clinician observation in evaluation of ASD. Autism Res2017, 10: 1672-1686. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据