期刊
CURRENT OPINION IN CELL BIOLOGY
卷 48, 期 -, 页码 106-112出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2017.06.007
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资金
- Japan Society for the Promotion of Science (JSPS) [26114001, 26250026, 15H0599006]
- AMED Strategic Japanese-Swiss Cooperative Program
- Naito Foundation
- Takeda Science Foundation
- Precursory Research for Embryonic Science and Technology (PRESTO) from the Japan Science and Technology Agency [PJ75160006]
- Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT) from the Japan Agency for Medical Research and Development (AMED) [PJ7516KD02]
- Ono Medical Research Foundation
- Grants-in-Aid for Scientific Research [26114001, 15K21757, 26250026] Funding Source: KAKEN
In the multi-cellular community, cells with different properties often compete with each other for survival and space. This process is named cell competition and was originally discovered in Drosophila. Recent studies have revealed that comparable phenomena also occur in mammals under various physiological and pathological conditions. Within the epithelium, normal cells often recognize the presence of the neighboring transformed cells and actively eliminate them from the epithelium; a process termed EDAC (Epithelial Defense Against Cancer). Furthermore, physical force can play a crucial role in the intercellular recognition and elimination of loser cells during cell competition. Further studies are expected to reveal a variety of roles of cell competition in embryonic development and human diseases.
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