期刊
WORLD JOURNAL OF SURGICAL ONCOLOGY
卷 15, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12957-017-1149-9
关键词
Rectal cancer; Concurrent chemoradiotherapy; Defunctioning ileostomy; Defunctioning colostomy; Low anterior resection; Early closure of a stoma
资金
- Excellence for Cancer Research Center Grant - Ministry of Science and Technology [MOST105-2325-B-037-001]
- Ministry of Health and Welfare [MOHW105-TDU-B-212-134007]
- Health and welfare surcharge of tobacco products, Taiwan, Republic of China
- Kaohsiung Medical University Hospital [KMUHS10522, KMUHS10505, KMUHS10418, KMUHGCRC2016002]
- Center for Biomarkers and Biotech Drugs, Kaohsiung Medical University [KMU-TP105C01, KMUTP105C11, KMU-TP106005, KMU-DK106005, SH000113]
- Research Center for Environmental Medicine, Kaohsiung Medical University [KMU-TP105A11, KMU-TP105A12]
- grant of Biosignature in Colorectal Cancers, Academia Sinica, Taiwan
Background: After a low anterior resection, creating a defunctioning stoma is vital for securing the anastomosis in low-lying rectal cancer patients receiving concurrent chemoradiotherapy. Although it decreases the complication and reoperation rates associated with anastomotic leakage, the complications that arise before and after stoma closure should be carefully evaluated and managed. Methods: This study enrolled 95 rectal cancer patients who received neoadjuvant concurrent chemoradiotherapy and low anterior resection with anastomosis of the bowel between July 2010 and November 2012. A defunctioning stoma was created in 63 patients during low anterior resection and in another three patients after anastomotic leakage. Results: The total complication rate from stoma creation to closure was 36.4%. Ileostomy led to greater renal insufficiency than colostomy did and significantly increased the readmission rate (all p < 0.05). The complication rate related to stoma closure was 36.0%. Patients with ileostomy had an increased risk of developing complications (p = 0.017), and early closure of the defunctioning stoma yielded a higher incidence of morbidity (p = 0.006). Multivariate analysis revealed that a time to closure of = 109 days was an independent risk factor for developing complications (p = 0.007). Conclusions: The optimal timing of stoma reversal is at least 109 days after stoma construction in rectal cancer patients receiving concurrent chemoradiotherapy and low anterior resection.
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