期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 313, 期 4, 页码 E450-E462出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00093.2017
关键词
aromatase; insulin sensitivity; inflammation; estrogen; adipose tissue
资金
- Swedish Research Council
- Swedish government [under the Avtal om Lakarutbildning och Medicinsk Forskning (Agreement for Medical Education and Research)]
- Lundberg Foundation
- Torsten Soderberg Foundation
- Novo Nordisk Foundation
- Knut and Alice Wallenberg Foundation
- Novo Nordisk Fonden [NNF16OC0021202, NNF15OC0016400, NNF14OC0009795, NNF16OC0021338, NNF15OC0016220, NNF14OC0010513, NNF13OC0004839, NNF15OC0016484, NNF14OC0009883, NNF17OC0026712, NNF15OC0015080, NNF16OC0021214, NNF13OC0005785] Funding Source: researchfish
Females are, in general, more insulin sensitive than males. To investigate whether this is a direct effect of sex-steroids (SS) in white adipose tissue (WAT), we developed a male mouse model overexpressing the aromatase enzyme, converting testosterone (T) to estradiol (E-2), specifically in WAT (Ap2-arom mice). Adipose tissue E2 levels were increased while circulating SS levels were unaffected in male Ap2-arom mice. Importantly, male Ap2-arom mice were more insulin sensitive compared with WT mice and exhibited increased serum adiponectin levels and upregulated expression of Glut4 and Irs1 in WAT. The expression of markers of macrophages and immune cell infiltration was markedly decreased in WAT of male Ap2-arom mice. The adipogenesis was enhanced in male Ap2-arom mice, supported by elevated Pparg expression in WAT and enhanced differentiation of preadipocyte into mature adipocytes. In summary, increased adipose tissue aromatase activity reduces adipose tissue inflammation and improves insulin sensitivity in male mice. We propose that estrogen increases insulin sensitivity via a local effect in WAT on adiponectin expression, adipose tissue inflammation, and adipogenesis.
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