期刊
DIABETES OBESITY & METABOLISM
卷 19, 期 10, 页码 1479-1484出版社
WILEY
DOI: 10.1111/dom.12953
关键词
continuous glucose monitoring; continuous subcutaneous insulin infusion; dietary intervention; dyslipidaemia; glycaemic control; hypoglycaemia
资金
- Danish Diabetes Academy - Novo Nordisk Foundation
- Danish Diabetes Association
- Poul and Erna Sehested Hansen Foundation
The aim of the present study was to assess the effects of a high carbohydrate diet (HCD) vs a low carbohydrate diet (LCD) on glycaemic variables and cardiovascular risk markers in patients with type 1 diabetes. Ten patients (4 women, insulin pump-treated, median +/- standard deviation [s.d.] age 48 +/- 10years, glycated haemoglobin [HbA1c] 53 +/- 6 mmol/mol [7.0% +/- 0.6%]) followed an isocaloric HCD (>= 250g/d) for 1week and an isocaloric LCD (<= 50g/d) for 1week in random order. After each week, we downloaded pump and sensor data and collected fasting blood and urine samples. Diet adherence was high (225 +/- 30 vs 47 +/- 10g carbohydrates/d; P < .0001). Mean sensor glucose levels were similar in the two diets (7.3 +/- 1.1 vs 7.4 +/- 0.6 mmol/L; P = .99). The LCD resulted in more time with glucose values in the range of 3.9 to 10.0 mmol/L (83% +/- 9% vs 72% +/- 11%; P = .02), less time with values <= 3.9 mmol/L (3.3% +/- 2.8% vs 8.0% +/- 6.3%; P = .03), and less glucose variability (s.d. 1.9 +/- 0.4 vs 2.6 +/- 0.4 mmol/L; P = .02) than the HCD. Cardiovascular markers were unaffected, while fasting glucagon, ketone and free fatty acid levels were higher at end of the LCD week than the HCD week. In conclusion, the LCD resulted in more time in euglycaemia, less time in hypoglycaemia and less glucose variability than the HCD, without altering mean glucose levels.
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