期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 23, 期 15, 页码 2705-2715出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v23.i15.2705
关键词
Hwangryunhaedok-tang; Gastrointestinal motility; Intestinal transit rate; Gastric emptying; Gastroprokinetic
资金
- National Research Foundation of Korea Grant - Korean Government (MSIP) [2014R1A5A2009936]
AIM To investigate the effects of Hwangryunhaedok-tang (HHT) on gastrointestinal (GI) motility in mice. METHODS The effects of a boiling water extract of HHT (HHTE) on GI motility were investigated by calculating percent intestinal transit rates (ITR%) and gastric emptying (GE) values using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). In addition, the effects of the four components of HHT, that is, Gardeniae Fructus (GF), Scutellariae Radix (SR), Coptidis Rhizoma (CR), and Phellodendri Cortex (PC), on GI motility were also investigated. RESULTS In normal ICR mice, ITR% and GE values were significantly and dose- dependently increased by the intragastric administration of HHTE (0.1-1 g/ kg). The ITR% values of GMD mice were significantly lower than those of normal mice, and these reductions were significantly and dose- dependently inhibited by HHTE (0.1-1 g/ kg). Additionally, GF, CR, and PC dose-dependently increased ITR% and GE values in normal and GMD mice. CONCLUSION These results suggest that HHT is a novel candidate for the development of a gastroprokinetic agent for the GI tract.
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