期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 23, 期 15, 页码 2750-2756出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v23.i15.2750
关键词
Obesity; Helicobacter pylori; retrospective study; China
资金
- State Key Laboratory of Pathogen and Biosecurity (Academy of Military Medical Science) [SKLPBS1442]
- Youth Talent Support Program of the School of Public Health, Peking University
AIM To explore the association between Helicobacter pylori (H. pylori) infection and obesity/weight gain in a Chinese population. METHODS Our primary outcome was the change in body mass index (BMI). The generalized linear models were used to explore the association between H. pylori infection and the change of BMI, and the logistic regression models were used to explore the association between H. pylori infection and obesity. RESULTS A total of 3039 subjects were recruited and analyzed, of which 12.8% were obese. The prevalence of H. pylori infection was 53.9% (1639/3039) overall and 54.6% (212/388) in the obese subjects. The change of BMI in the H. pylori (+) group was not significantly higher than that in the H. pylori (-) group after adjustment for potential confounding factors [RR = 0.988, 95%CI: 0.924-1.057, P = 0.729]. The prevalence of obesity decreased 1.1% in the H. pylori (+) group and 0.5% in the H. pylori (-) group. The RR of H. pylori infection for obesity was 0.831 (95%CI: 0.577-1.197, P = 0.321) after the adjustment. CONCLUSION H. pylori infection was not associated with overweight/obesity observed from the retrospective study in this Chinese population.
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