期刊
BIORESOURCE TECHNOLOGY
卷 241, 期 -, 页码 430-438出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2017.05.168
关键词
Escherichia coli; Isoprenoids; Metabolic engineering; Synthetic biology
资金
- NRF - MSIP [NRF2016M3D3A1A01913246]
- National Research Foundation, MSIP, Korea [NRF-2016R1A2B2010678]
- National Research Foundation of Korea [2016R1A2B2010678, 2016M3D3A1A01913246] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Isoprenoids comprise the largest family of natural organic compounds with many useful applications in the pharmaceutical, nutraceutical, and industrial fields. Rapid developments in metabolic engineering and synthetic biology have facilitated the engineering of isoprenoid biosynthetic pathways in Escherichia coli to induce high levels of production of many different isoprenoids. In this review, the stem pathways for synthesizing isoprene units as well as the branch pathways deriving diverse isoprenoids from the isoprene units have been summarized. The review also highlights the metabolic engineering efforts made for the biosynthesis of hemiterpenoids, monoterpenoids, sesquiterpenoids, diterpenoids, carotenoids, retinoids, and coenzyme Q(10) in E. coli. Perspectives and future directions for the synthesis of novel isoprenoids, decoration of isoprenoids using cytochrome P450 enzymes, and secretion or storage of isoprenoids in E. coli have also been included. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据