期刊
EMBO REPORTS
卷 18, 期 10, 页码 1837-1853出版社
WILEY
DOI: 10.15252/embr.201744147
关键词
ceRNA; gallbladder cancer; lncRNA; PAGBC; prognosis
资金
- National Natural Science Foundation of China [81502433, 31620103910, 91440203]
- Program for Changjiang Scholars
- Leading Talent Program of Shanghai
- Shanghai RisingStar Program [15QA1403100]
- Shanghai Science and Technology Commission Key Basic Research Program [16JC1400200]
- Key Program of Shanghai Science and Technology Commission [16411952501]
- Multiple Central Clinical Research Program of Shanghai Jiao Tong University School of Medicine [DLY201507]
- Precision Medicine Research Program of Shanghai Jiao Tong University School of Medicine [15ZH4003]
- Doctoral Innovation Fund Projects from Shanghai Jiao Tong University School of Medicine [BXJ201426]
- Hangzhou Science and Technology Commission Project [20140633B04]
Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据