期刊
DIABETOLOGIA
卷 60, 期 10, 页码 1903-1912出版社
SPRINGER
DOI: 10.1007/s00125-017-4380-6
关键词
Biomarkers; Gestational diabetes; Lipids; Obesity; Pregnancy; Targeted metabolome
资金
- National Institute of Health Research [RP-PG-0407-10452]
- Medical Research Council UK [MR/L002477/1]
- Chief Scientist Office
- Scottish Government Health Directorates (Edinburgh) [CZB/A/680]
- Biomedical Research Centre at Guys & St Thomas NHS Foundation Trust & King's College London
- NIHR Bristol Biomedical Research Centre, Tommy's Charity, UK [SC039280]
- Diabetes UK [14/0004849]
- UK Medical Research Council
- Chief Scientist Office [CZB/4/680] Funding Source: researchfish
- Medical Research Council [MC_UU_12013/5, MR/L002477/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10196, RP-PG-0407-10452, CL-2010-17-007] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [RP-PG-0407-10452] Funding Source: National Institutes of Health Research (NIHR)
- MRC [MC_UU_12013/5, MR/L002477/1] Funding Source: UKRI
Aims/hypothesis Antenatal obesity and associated gestational diabetes (GDM) are increasing worldwide. While pre-existing insulin resistance is implicated in GDM in obese women, the responsible metabolic pathways remain poorly described. Our aim was to compare metabolic profiles in blood of obese pregnant women with and without GDM 10 weeks prior to and at the time of diagnosis by OGTT. Methods We investigated 646 women, of whom 198 developed GDM, in this prospective cohort study, a secondary analysis of UK Pregnancies Better Eating and Activity Trial (UPBEAT), a multicentre randomised controlled trial of a complex lifestyle intervention in obese pregnant women. Multivariate regression analyses adjusted for multiple testing, and accounting for appropriate confounders including study intervention, were performed to compare obese women with GDM with obese non-GDM women. We measured 163 analytes in serum, plasma or whole blood, including 147 from a targeted NMR metabolome, at time point 1 (mean gestational age 17 weeks 0 days) and time point 2 (mean gestational age 27 weeks 5 days, at time of OGTT) and compared them between groups. Results Multiple significant differences were observed in women who developed GDMcompared with women without GDM (false discovery rate corrected p values < 0.05). Most were evident prior to diagnosis. Women with GDM demonstrated raised lipids and lipoprotein constituents in VLDL subclasses, greater triacylglycerol enrichment across lipoprotein particles, higher branched-chain and aromatic amino acids and different fatty acid, ketone body, adipokine, liver and inflammatory marker profiles compared with those without GDM. Conclusions/interpretation Among obese pregnant women, differences in metabolic profile, including exaggerated dyslipidaemia, are evident at least 10 weeks prior to a diagnosis of GDM in the late second trimester.
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