期刊
NEUROREHABILITATION AND NEURAL REPAIR
卷 31, 期 10-11, 页码 864-876出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1545968317732680
关键词
Biomarker; motor; somatosensory; cognition; language; stratification; function; clinical trial; neuroimaging; human
资金
- Canada Research Chairs
- MSFHR [CI-SCH-01796]
- NHMRC [1088449]
- Micheal Smith Foundation for Health Research (MSFHR) [15980]
- NIH [K24 HD074722]
- University of Queensland Vice Chancellor's Fellowship
- National Health and Medical Research Council (NHMRC) grants [1022694, 307905]
- James S. McDonnell Foundation 21st Century Science Initiative in Cognitive Rehabilitation - Collaborative Award [220020413]
- NHMRC CRE in Stroke Rehabilitation and Brain Injury [1077898]
- Australian Research Council Future Fellowship [FT0992299]
- National Health and Medical Research Council of Australia [1077898, 1088449] Funding Source: NHMRC
The most difficult clinical questions in stroke rehabilitation are What is this patient's potential for recovery? and What is the best rehabilitation strategy for this person, given her/his clinical profile? Without answers to these questions, clinicians struggle to make decisions regarding the content and focus of therapy, and researchers design studies that inadvertently mix participants who have a high likelihood of responding with those who do not. Developing and implementing biomarkers that distinguish patient subgroups will help address these issues and unravel the factors important to the recovery process. The goal of the present paper is to provide a consensus statement regarding the current state of the evidence for stroke recovery biomarkers. Biomarkers of motor, somatosensory, cognitive and language domains across the recovery timeline post-stroke are considered; with focus on brain structure and function, and exclusion of blood markers and genetics. We provide evidence for biomarkers that are considered ready to be included in clinical trials, as well as others that are promising but not ready and so represent a developmental priority. We conclude with an example that illustrates the utility of biomarkers in recovery and rehabilitation research, demonstrating how the inclusion of a biomarker may enhance future clinical trials. In this way, we propose a way forward for when and where we can include biomarkers to advance the efficacy of the practice of, and research into, rehabilitation and recovery after stroke.
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