期刊
CLINICAL NEUROPHYSIOLOGY
卷 128, 期 10, 页码 1923-1936出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2017.07.004
关键词
Depression; Mismatch negativity; Pitch; Musical multi-feature paradigm; Magnetoenchephalography (MEG)
资金
- Danish National Research Foundations's Center for Music in the Brain (Aarhus University, Denmark)
- Cognitive Brain Research Unit, Institute of Behavioral Sciences (University of Helsinki, Finland)
Objective: Depression is a state of aversion to activity and low mood that affects behaviour, thoughts, feelings and sense of well-being. Moreover, the individual depression trait is associated with altered auditory cortex activation and appraisal of the affective content of sounds.& para;& para;Methods: Mismatch negativity responses (MMNs) to acoustic feature changes (pitch, timbre, location, intensity, slide and rhythm) inserted in a musical sequence played in major or minor mode were recorded using magnetoencephalography (MEG) in 88 subclinical participants with depression risk.& para;& para;Results: We found correlations between MMNs to slide and pitch and the level of depression risk reported by participants, indicating that higher MMNs correspond to higher risk of depression. Furthermore we found significantly higher MMN amplitudes to mistuned pitches within a major context compared to MMNs to pitch changes in a minor context.& para;& para;Conclusions: The brains of individuals with depression risk are more responsive to mistuned and fast pitch stimulus changes, even at a pre-attentive level.& para;& para;Significance: Considering the altered appraisal of affective contents of sounds in depression and the relevance of spectral pitch features for those contents in music and speech, we propose that individuals with subclinical depression risk are more tuned to tracking sudden pitch changes. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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