期刊
DATA IN BRIEF
卷 14, 期 -, 页码 197-205出版社
ELSEVIER
DOI: 10.1016/j.dib.2017.07.033
关键词
Reperfusion injury; Myocardial infarction; PCI; Cyclosporin; Nicorandil; Follow-up
资金
- MRC [G1001340] Funding Source: UKRI
Mortality and morbidity in patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) are still high [1]. A huge amount of the myocardial damage is related to the mitochondrial events happening during reperfusion [2]. Several drugs directly and indirectly targeting mitochondria have been administered at the time of the PCI and their effect on fatal (all-cause mortality, cardiovascular (CV) death) and non fatal (hospital readmission for heart failure (HF)) outcomes have been tested showing conflicting results [3-16]. Data from 15 trials have been pooled with the aim to analyze the effect of drug administration versus placebo on outcome [17]. Subgroup analysis are here analyzed: considering only randomized clinical trial (RCT) on cyclosporine or nicorandil [3-5,9-11], excluding a trial on metoprolol [12] and comparing trial with follow-up length < 12 months versus those with longer follow-up [3-16]. This article describes data related article titled Clinical Benefit of Drugs Targeting Mitochondrial Function as an Adjunct to Reperfusion in ST-segment Elevation Myocardial Infarction: a Meta-Analysis of Randomized Clinical Trials [17]. (C) 2017 The Authors. Published by Elsevier Inc.
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