期刊
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
卷 19, 期 6, 页码 412-420出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/15622975.2017.1331046
关键词
Silexan; lavender oil; anxiety disorder; clinical trial; pharmacology
类别
资金
- Angelini
- AOP Orphan Pharmaceuticals AG
- AstraZeneca
- Eli Lilly
- Janssen
- KRKA-Pharma
- Lundbeck
- Neuraxpharm
- Pfizer
- Pierre Fabre
- Schwabe
- Servier
- UCB
- Lundbeck GmbH
- Pfizer Pharma GmbH
- Otsuka Pharma GmbH
- Dr. Willmar-Schwabe GmbH Co. KG
- Bayer vital GmbH
- Janssen-Cilag GmbH
- neuraxpharm GmbH
- AstraZeneca GmbH
- Lilly Deutschland GmbH
- Servier Deutschland GmbH
Objectives: Silexan is a lavender oil preparation available in 80-mg capsules. Here we review clinical trials investigating its anxiolytic efficacy, safety and tolerability in humans, as well as preclinical investigations supporting this therapeutic use.Methods: Besides three selected publications reporting preclinical investigations, seven clinical trials are included, of which five had a treatment duration of 6 or 10 weeks. Primary outcome measure was the HAM-A total score reduction, while single items were assessed with regard to effects on concomitant depressive symptoms and on quality of sleep.Results: In patients with subthreshold (subsyndromal) anxiety or generalised anxiety disorder (GAD), an anxiolytic effect of Silexan was evident after 2 weeks. HAM-A total score reductions between baseline and end of treatment were significantly superior to placebo in patients with subthreshold anxiety and comparable with those achieved under lorazepam or paroxetine in patients with GAD. In addition, Silexan had beneficial effects on typical concomitant symptoms of anxiety disorders, such as impaired sleep, somatic complaints, co-morbid depression or decreased quality of life. Except for mild gastrointestinal symptoms, Silexan did not induce any adverse effects and did not cause drug interactions, sedation or withdrawal symptoms at daily doses of 80 or 160mg.Conclusions: Silexan is a safe and effective treatment in anxiety disorders.
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