期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 74, 期 19, 页码 3491-3507出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2536-7
关键词
Platelets; Cancer cells; Metastasis; Aspirin; Antiplatelet agents; Prostaglandin E-2; Epithelial-mesenchymal transitions
资金
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) [2010FHH32M]
- Associazione Italiana per la Ricerca sul Cancro [IG-12111]
Platelets are anucleated cells that circulate in the blood as sentinels of tissue integrity. In fact, they are rich in a plethora of proteins and other factors stored in different granules which they selectively release upon stimulation. Moreover, platelets synthesize a vast number of lipids and release various types of vesicles, including exosomes which are rich in genetic material. Platelets possess a central function to interact with other cell types, including inflammatory cells and cancer cells. Recent findings have enlightened the capacity of platelets to induce changes in the phenotype of cancer cells which acquire invasiveness thus enhancing their metastatic potential. Thus, it has been hypothesized that targeting the platelet may represent a novel strategy to prevent the development and progression of cancer. This is supported by the efficacy of the anti-platelet agent low-dose aspirin. Studies are ongoing to verify whether other antiplatelet agents share the anticancer effectiveness of aspirin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据