期刊
CHEMISTRY AND PHYSICS OF LIPIDS
卷 207, 期 -, 页码 192-205出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2017.03.001
关键词
Antioxidants; Phytochemicals; Oxysterols; Cholesterol oxidation products; Phytosterol oxidation products; Human chronic diseases
资金
- Spanish Ministry of Economy and Competitiveness [AGL2015-68006-C2-1-R]
The intake of fruits and vegetables is associated with reduced incidence of many chronic diseases. These foods contain phytochemicals that often possess antioxidant and free radical scavenging capacity and show anti-inflammatory action, which are also the basis of other bioactivities and health benefits, such as anticancer, anti-aging, and protective action for cardiovascular diseases, diabetes mellitus, obesity and neurodegenerative disorders. Many factors can be included in the etiopathogenesis of all of these multifactorial diseases that involve oxidative stress, inflammation and/or cell death processes, oxysterols, i.e. cholesterol oxidation products (COPs) as well as phytosterol oxidation products (POPs), among others. These oxidized lipids result from either spontaneous and/or enzymatic oxidation of cholesterol/phytosterols on the steroid nucleus or on the side chain and their critical roles in the pathophysiology of the abovementioned diseases has become increasingly evident. In this context, many studies investigated the potential of dietary phytochemicals (polyphenols, carotenoids and vitamins C and E, among others) to protect against oxysterol toxicity in various cell models mimicking pathophysiological conditions. This review, summarizing the mechanisms involved in the chemopreventive effect of phytochemicals against the injury by oxysterols may constitute a step forward to consider the importance of preventive strategies on a nutritional point of view to decrease the burden of many age-related chronic diseases. (C) 2017 Elsevier B.V. All rights reserved.
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