期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 41, 页码 12614-12618出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201707164
关键词
cucurbit[n]uril; drug delivery; host-guest systems; molecular recognition; stimuli response
资金
- Natural Science Foundation of China [51503042, 21672042]
- ShanghaiTech University Startup Fund
Stimuli-responsive molecular containers are of great importance for controlled drug delivery and other biomedical applications. A new type of acid labile acyclic cucurbit[n]uril (CB[n]) molecular containers is presented that can degrade and release the encapsulated cargo at accelerated rates under mildly acidic conditions (pH 5.5-6.5). These containers retain the excellent recognition properties of CB[n]-type hosts. A cell culture study demonstrated that the cellular uptake of cargos could be fine-tuned by complexation with different containers. The release and cell uptake of cargo dye was promoted by acidic pH.
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