期刊
SUBSTANCE ABUSE TREATMENT PREVENTION AND POLICY
卷 12, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13011-017-0126-1
关键词
Opioid substitution therapy; HIV prevention; HCV prevention; People who inject drugs; Methadone; Opioid agonist treatment; Injection initiation assistance
资金
- Fogarty International Center of the National Institutes of Health (NIH) [D43TW008633, R25TW009343]
- UC San Diego Center for AIDS Research (CFAR) [NIAID P30AI36214]
- National Institute of Drug Abuse (NIDA) [T32DA023356]
- NIH [1TL1TR001443]
- NIDA [R01DA031074]
- NIDA MERIT award [R37DA019829]
- US NIDA Avenir Award [DP2- DA040256- 01]
- Canadian Institutes of Health Research
Background: Medication-assisted treatment (MAT) remains the gold standard for the treatment of opioid use disorder. MAT also reduces the frequency of injecting among people who inject drugs (PWID). Relatedly, data suggest that PWID play a key role in the initiation of others into drug injecting by exposing injecting practices to injection-naive drug users. Our primary objective was to test whether a history of MAT enrollment is associated with a reduced odds of PWID providing injection initiation assistance. Methods: Preventing Injecting by Modifying Existing Responses (PRIMER; NIDA DP2-DA040256-01), is a multi-site cohort study assessing the impact of socio-structural factors on the risk that PWID provide injection initiation assistance. Data were drawn from a participating cohort of PWID in San Diego, CA. The primary outcome was reporting ever providing injection initiation assistance; the primary predictor was reporting ever being enrolled in MAT. Logistic regression was used to model associations between MAT enrollment and ever initiating others into injecting while adjusting for potential confounders. Results: Participants (n = 354) were predominantly male (n = 249, 70%). Thirty-eight percent (n = 135) of participants reported ever initiating others into injection drug use. In multivariate analysis, participants who reported a history of MAT enrollment had significantly decreased odds of ever providing injection initiation assistance (Adjusted Odds Ratio [AOR]: 0.62, 95% Confidence Interval [CI]: 0.39-0.99). Conclusions: These preliminary findings suggest an association between MAT enrollment and a lower odds that male PWID report providing injection initiation assistance to injection-naive drug users. Further research is needed to identify the pathways by which MAT enrollment may impact the risk that PWID initiate others into drug injecting.
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