期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 42, 页码 13088-13093出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201707906
关键词
amination; arylation; cross-coupling; electrochemistry; nickel
资金
- NIH [GM-118176]
- Pfizer
- China Scholarship Council (CSC)
- Hewitt Foundation
- JSPS
- GlaxoSmithKline/University of Strathclyde
Along with amide bond formation, Suzuki cross-coupling, and reductive amination, the Buchwald-Hartwig-Ullmann-type amination of aryl halides stands as one of the most employed reactions in modern medicinal chemistry. The work herein demonstrates the potential of utilizing electrochemistry to provide a complementary avenue to access such critical bonds using an inexpensive nickel catalyst under mild reaction conditions. Of note is the scalability, functional-group tolerance, rapid rate, and the ability to employ a variety of aryl donors (Ar-Cl, Ar-Br, Ar-I, Ar-OTf), amine types (primary and secondary), and even alternative X-H donors (alcohols and amides).
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