期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 42, 页码 13126-13129出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201706974
关键词
fluorescent dyes; imaging agents; near-infrared; polymethines; shortwave infrared
资金
- UCLA, MITHarvard Center for Excitonics EFRC (DOE) [DE-SC0001088]
- Laser Biomedical Research Center (NIH) [5-P41-EB015871-29]
- NSF MRI [CHE-1048804]
- Boehringer Ingelheim Fonds
- NSF GRFP [DGE-1144087]
Bright fluorophores in the near-infrared and shortwave infrared (SWIR) regions of the electromagnetic spectrum are essential for optical imaging invivo. In this work, we utilized a 7-dimethylamino flavylium heterocycle to construct a panel of novel red-shifted polymethine dyes, with emission wavelengths from 680 to 1045nm. Photophysical characterization revealed that the 1- and 3-methine dyes display enhanced photostability and the 5- and 7-methine dyes exhibit exceptional brightness for their respective spectral regions. A micelle formulation of the 7-methine facilitated SWIR imaging in mice. This report presents the first polymethine dye designed and synthesized for SWIR invivo imaging.
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