期刊
ACTA BIOMATERIALIA
卷 62, 期 -, 页码 273-283出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2017.08.024
关键词
Hollow mesoporous silica; Gold nanostars; RGD targeting; Tumors; Chemo-iphotothermal therapy
资金
- Science and Technology Commission of Shanghai Municipality [15520711400, 17540712000]
- Fundamental Research Funds for the Central Universities
- National Natural Science Foundation of China [81761148028, 21773026, 81571679, 81271596]
- FCT-Foundation for Science and Technology [PEst-OE/QUI/UI0674/2013]
- [M1420-01-0145-FEDER-000005]
- [Madeira 14-20]
The combination of chemotherapy and photothermal therapy (PTT) in multifunctional nanoplatforms to improve cancer therapeutic efficacy is of great significance while it still remains to be a challenging task. Herein, we report Au nanostar (NS)-coated hollow mesoporous silica nanocapsules (HMSs) with surface modified by arginine-glycine-aspartic acid (RGD) peptide as a drug delivery system to encapsulate doxorubicin (DOX) for targeted chemotherapy and PIT of tumors. Au NSs-coated HMSs core/shell nanocapsules (HMSs@Au NSs) synthesized previously were conjugated with RGD peptide via a spacer of polyethylene glycol (PEG). We show that the prepared HMSs@Au-PEG-RGD NSs are non-cytotxic in the given concentration range, and have a DOX encapsulation efficiency of 98.6 +/- 0.7%. The designed HMSs@Au-PEG-RGD NSs/DOX system can release DOX in a pH/NIR laser dual-responsive manner. Importantly, the formed HMSs@Au-PEG-RGD NSs/DOX nanoplatform can specifically target cancer cells overexpressing alpha(V beta 3) intergrin and exert combination chemotherapy and PTT efficacy to the cells in vitro and a xenografted tumor model in vivo. Our results suggest that the designed HMSs@Au-PEG-RGD NSs/DOX nanoplatform may be used for combination chemotherapy and PTT of tumors.
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