期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 45, 期 -, 页码 1149-1158出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20170048
关键词
-
资金
- National Science Foundation [MCB-1515521, CHE-1608146]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1515521] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1608146] Funding Source: National Science Foundation
The Holliday junction (HJ) is an essential element in recombination and related mechanisms. The structure of this four-stranded DNA assembly, which is now well-defined alone and in complex with proteins, has led to its applications in areas well outside of molecular recombination, including nanotechnology and biophysics. This minireview explores some interesting recent research on the HJ, as it has been adapted to design regular two-or three-dimensional lattices for crystal engineering, and more complex systems through DNA origami. In addition, the sequence dependence of the structure is discussed in terms how it can be applied to characterize the geometries and energies of various non-covalent interactions, including halogen bonds in oxidatively damaged (halogenated) bases and hydrogen bonds associated with the epigenetic 5-hydroxylmethylcytosine base.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据