期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 632, 期 -, 页码 104-117出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2017.06.022
关键词
Enzyme mechanism; Flavoprotein; Oxidoreductase; Phylogeny; Protein family
资金
- European Union through INDOX project [FP7-KBBE-2013-7-613549]
The VAO/PCMH flavoprotein family consists of structurally homologous flavin-dependent enzymes that catalyze a wide range of chemical reactions. Family members share an architecture consisting of a conserved FAD-binding domain and a more variable substrate-binding domain, which enables varying interactions with a range of substrates while maintaining the same cofactor-binding fold. Here, we provide an overview of the current state of our knowledge on the members of the VAO/PCMH family. Based on a phylogenetic analysis, we divide the family into 11 subgroups. We discuss the properties of these subgroups, focusing on recent developments in terms of the discovery of new family members and mechanistic advances. We also highlight open questions that will provide challenges for future research. (C) 2017 Elsevier Inc. All rights reserved.
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