期刊
CARBOHYDRATE POLYMERS
卷 174, 期 -, 页码 48-56出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.06.051
关键词
Curculigo orchioides Gaertn; O-acetyl-glucomannan; Structural characterization; Anti-osteoporosis; Primary osteoblasts
资金
- National Natural Science Foundation of China [81673557, 81274060, 81102779]
- Guangdong Natural Science Foundation [9451022401003453]
- Pearl River S&T Nova Program of Guangzhou [2013J2200035]
- Innovation Program of the University of Guangdong Province [2014KTSCX118]
- Science and Technology Program of Guangdong Province [2014A050503067, 2015A020211032]
- High-level Talents Program of the University of Guangdong Province
Osteoporosis is characterized by a reduction in bone mass and bone mineral density, which weakens the bone. Due to the side effects associated with drugs that are currently used to treat this disease, an increasing number of studies have focused on the research of effective ingredients derived from natural products. In particular, polysaccharides extracted from Chinese herbal medicines have received increasing attention. In this study, we isolated a homogeneous polysaccharide (COP90-1) from the dried rhizomes of Curculigo orchioides, a famous traditional Chinese medicine that is widely used in China, and determined its structure using the combined methods of chemical and spectral analyses. In addition, its effects on the proliferation and differentiation of primary mouse osteoblasts were assessed. The results showed that COP90-1 can effectively promote the proliferation and differentiation of primary osteoblasts in vitro. Additional studies are warranted to study the effects of this compound in vivo. (C) 2017 Elsevier Ltd. All rights reserved.
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