期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 43, 页码 13342-13346出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201708224
关键词
copper; fluorine; fluoroalkanes; hydrodefluorination; Zselectivity
资金
- 1000-Youth Talents Plan
- NSF of China [2167020084, 21401099]
A copper catalytic system was established for the stereoselective hydrodefluorination of gem-difluoroalkenes through C-F activation to synthesize various Zfluoroalkenes. H2O is used as the hydrogen source for the fluorine acceptor moiety. This mild catalytic system shows good-functional group compatibility, accepting a range of carbonyls as precursors to the gem-difluoroalkenes, including aliphatic, aromatic, and ,-unsaturated aldehydes and even ketones. It serves as a powerful synthetic method for the late-stage modification of complex compounds.
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