4.8 Article

Active Antioxidizing Particles for On-Demand Pressure-Driven Molecular Release

期刊

ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 41, 页码 35642-35650

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b12297

关键词

oxidative damage; hydrogen peroxide (H2O2); MnO2 nanosheets; poly(lactic-co-glycolic acid) (PLGA) particle; epigallocatechin gallate (EGCG)

资金

  1. National Institutes of Health [1R01 HL109192, 1U01 MH 109062]
  2. National Science Foundation (STC-EBICS) [CBET-0939511, DBI 14-50962 EAGER, CBET-1009465]
  3. Department of Defense [W81XWH-17-1-022]
  4. Agency for Science, Technology, and Research (A*STAR)
  5. Direct For Biological Sciences
  6. Div Of Biological Infrastructure [1450962] Funding Source: National Science Foundation

向作者/读者索取更多资源

Overproduced reactive oxygen species (ROS) are closely related to various health problems including inflammation, infection, and cancer. Abnormally high ROS levels can cause serious oxidative damage to biomolecules, cells, and tissues. A series of nano- or microsized particles has been developed to reduce the oxidative stress level by delivering antioxidant drugs. However, most systems are often plagued by slow molecular discharge, driven by diffusion. Herein, this study demonstrates the polymeric particles whose internal pressure can increase upon exposure to H2O2, one of the ROS, and in turn, discharge antioxidants actively. The on-demand pressurized particles are assembled by simultaneously encapsulating water-dispersible manganese oxide (MnO2) nanosheets and green tea derived epigallocatechin gallate (EGCG) molecules into a poly(lactic-co-glycolic acid) (PLGA) spherical shell. In the presence of H2O2, the MnO2 nanosheets in the PLGA particle generate oxygen gas by decomposing H2O2 and increase the internal pressure. The pressurized PLGA particles release antioxidative EGCG actively and, in turn, protect vascular and brain tissues from oxidative damage more effectively than the particles without MnO2 nanosheets. This H2O2 responsive, self-pressurizing particle system would be useful to deliver a wide array of molecular cargos in response to the oxidation level.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据