期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 41, 页码 12628-12633出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201707350
关键词
luminescence; metallo-intercalators; photodynamic therapy; ruthenium(II); singlet oxygen
资金
- KRG-Scholarship Human Capacity Development Program (HCDP)
- EPSRC
- UoS
- Engineering and Physical Sciences Research Council [1614878, EP/M015572/1] Funding Source: researchfish
- EPSRC [EP/M015572/1] Funding Source: UKRI
Using a new mononuclear building block, for the first time, a dinuclear Ru-II(dppn) complex and a heteroleptic system containing both Ru-II(dppz) and Ru-II(dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are O-1(2) sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence switch on DNA light-switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.
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