期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 116, 期 -, 页码 21-36出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2016.06.004
关键词
Solute Carrier Transporters; Drug pharmacokinetics; Pharmacogenomics; Organic anion transporting polypeptides; Organic anion transporters; Organic cation transporters
资金
- National Health and Medical Research Council of Australia [GNT1025101]
Drug pharmacokinetics is influenced by the function of metabolising enzymes and influx/efflux transporters. Genetic variability of these genes is known to impact on clinical therapies. Solute Carrier Transporters (SLCs) are the primary influx transporters responsible for the cellular uptake of drug molecules, which consequently, impact on drug efficacy and toxicity. The Organic Anion Transporting Polypeptides (OATPs), Organic Anion Transporters (OATs) and Organic Cation Transporters (OCTs/OCTNs) are the most important SLCs involved in drug disposition. The information regarding the influence of SLC polymorphisms on drug pharmacokinetics is limited and remains a hot topic of pharmaceutical research. This review summarises the recent advance in the pharmacogenomics of SLCs with an emphasis on human OATPs, OATs and OCTs/OCTNs. Our current appreciation of the degree of variability in these transporters may contribute to better understanding the inter-patient variation of therapies and thus, guide the optimisation of clinical treatments. (C) 2016 Elsevier B.V. All rights reserved.
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