期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 44, 页码 13684-13688出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201707137
关键词
anticancer therapy; bilirubin nanoparticles; cisplatin; photoacoustic imaging; photothermal therapy
资金
- Global Research Laboratory through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2012K1A1A2045436]
Bilirubin (BR), a bile pigment that exerts potent antioxidant and anti-inflammatory effects, is also a major constituent of black pigment gallstones found in bile ducts under certain pathological conditions. Inspired by the intrinsic metal-chelating power of BR found in gallstones, herein we report a cisplatin-chelated BR-based nanoparticle (cisPt@BRNP) for use as a new photonic nanomedicine for combined photoacoustic imaging and photothermal therapy of cancers. The cisPt@BRNPs were prepared by simply mixing cisplatin with BRNPs, yielding ca. 150-nm-size NPs. Upon near-IR laser irradiation at 808 nm, cisPt@BRNPs generated considerable heat and induced clear death of cancer cells in vitro. Following intravenous injection into human colon cancer-bearing mice, cisPt@BRNPs allowed effective tumor visualization by photoacoustic imaging and remarkable antitumor efficacy by photothermal therapy, suggesting their potential for use as a new photonic nanomedicine for cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据