期刊
CURRENT BIOLOGY
卷 27, 期 20, 页码 3168-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2017.08.068
关键词
-
资金
- Ministry of Science, ICT and Future Planning [17-BD-06, 17-BR-04, 17-BR-02]
- National Research Foundation of Korea [NRF-2015R1D1A1A09061430, NRF-2017R1A4A1015534]
- NIH [R15GM111094, R01GM087533]
- NSF IOS [1256488, 1655118]
- KBSI [T37416]
- Ministry for Health and Welfare [HI14C1135]
- Ministry of Science & ICT (MSIT), Republic of Korea [17-BR-04, 17-BR-02, 17-BD-06] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1655118, 1256488] Funding Source: National Science Foundation
Experiences during early development can influence neuronal functions and modulate adult behaviors [1, 2]. However, the molecular mechanisms underlying the long-term behavioral effects of these early experiences are not fully understood. The C. elegans ascr#3 (asc-Delta C9; C9) pheromone triggers avoidance behavior in adult hermaphrodites [3-7]. Here, we show that hermaphrodites that are briefly exposed to ascr#3 immediately after birth exhibit increased ascr#3-specific avoidance as adults, indicating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr# 3 exposure [8]. ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons and their post-synaptic SMB motor neuron partners via increased expression of the odr-2 glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons. Our study suggests that the memory for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity in adult ascr#3 responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据