期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 359, 期 20, 页码 3648-3653出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201700712
关键词
Phenols; Amines; Deoxygenation; N-N/O cleavage; Hydrazine; Palladium
资金
- Canada Research Chair Foundation
- CFI
- FQRNT Center for Green Chemistry and Catalysis
- NSERC
- McGill University
Direct access to amines from biomass-based phenols via deoxygenative transformation remains greatly challenging in organic synthesis. Herein, we present a palladium-catalyzed deoxygenative amination of phenols (and their benzyl ether) with hydrazine as nitrogen source. The hydroxylamine/formic acid can be substituted for hydrazine in some cases. This deoxyamination features the involvement of a complex C-O bond and N-N/O bond-cleavage process and allows for the construction of N-substituted cyclohexyl anilines from an array of phenols by finely controlling the reaction conditions in moderate to good yields.
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